孤独感,表观遗传加速衰老,以及慢性健康状况
Colin D Freilich1, Kristian E Markon1, Steve W Cole2
1Department of Psychology, University of Minnesota Twin Cities.
Psychology and aging
|April 18, 2024
概括
孤独与健康风险有关,表观遗传衰老加速 (EAA) 可能发挥作用. 较高的EAA放大了孤独对健康的负面影响,表明复杂的生物途径.
科学领域:
- 心理学 心理学 心理学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 公共卫生 公共卫生
背景情况:
- 孤独是一个重要的公共卫生问题,与不良健康结果相关.
- 现有的研究还不能完全解释孤独与健康风险相关的机制.
- 表观遗传的影响,特别是DNA甲基化,被探索为潜在的解释因素.
研究的目的:
- 调查表观遗传衰老加速 (EAA) 是否调解或缓解孤独与慢性健康状况之间的关系.
- 用多个表观遗传钟来评估孤独与EAA之间的关联.
- 检查孤独和EAA对老年成人健康结果的纵向影响.
主要方法:
- 利用美国中年人群研究 (MIDUS) 的数据,对1310名参与者进行初始EAA分析.
- 使用Horvath,DunedinPACE和GrimAge表观遗传钟进行孤独和EAA的评估.
- 采用445名参与者的纵向随访数据来分析慢性健康状况的出现.
主要成果:
- 在多项措施中,在孤独度增加和EAA增加之间发现了一个微弱的关联,即使在对共变量进行控制之后.
- 孤独预测慢性疾病数量随着时间的推移而增加.
- 孤独对慢性疾病的影响在具有较高DunedinPACEEAA值的个体中更为明显,这表明潜在的相互作用.
结论:
- 表观遗传衰老加速 (EAA) 在阐明孤独对健康影响的个体变异方面表现有前途.
- 这些发现表明孤独和表观遗传衰老对健康的潜在协同作用.
- 需要进一步的研究才能充分理解这些关联背后的特定生物机制.
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