年轻黑人成年人的种族歧视和代谢综合征
Nia Heard-Garris1,2,3,4, Tianyi Yu5, Gene Brody5
1Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
JAMA network open
|April 18, 2024
概括
在青春晚期经历的种族歧视与黑人年轻成年人的代谢综合征 (MetS) 有关,由炎症和睡眠问题介导. 解决歧视问题对于健康公平至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 健康差异 在健康上的差异
背景情况:
- 代谢综合征 (MetS) 是心血管疾病 (CVD) 的重要危险因素.
- 黑人个人经历不成比例地更高的MetS率和更大的种族歧视.
- 种族歧视对黑人年轻成年人MetS发展的长期影响仍未得到充分研究.
研究的目的:
- 调查农村黑人从青春期过渡到早期成年期的种族歧视和MetS之间的关联.
- 在这种关联中识别潜在的调解途径,包括炎症和睡眠问题.
主要方法:
- 在格鲁吉亚农村地区的强大非裔美国家庭健康成年人 (SHAPE) 项目中对322名黑人青少年进行了纵向队列研究.
- 从19岁到21岁,每年对种族歧视进行评估.
- 根据国际糖尿病联合会的标准,MetS在25岁和31岁时被诊断出来;炎症标志物 (suPAR) 和睡眠问题在25岁时被测量出来.
主要成果:
- 增加的种族歧视暴露与更高的可溶性尿激酶激活体受体 (suPAR) 水平和25岁时更多的睡眠问题有关.
- 种族歧视与31岁时MetS诊断风险增加9.5%有关.
- 25岁时的suPAR和睡眠问题都显著调解了种族歧视和MetS之间的关系.
结论:
- 在青春晚期的种族歧视与黑人年轻人的MetS风险增加有关.
- 生物行为路径,包括炎症和睡眠障碍,调解了这种关联.
- 针对黑人成年人的MetS的干预措施应解决种族歧视,睡眠行为和炎症过程,以促进健康平等.
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