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Updated: Jun 28, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

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机器学习三维蛋白质结构来预测基因组变异的功能影响

Kriti Shukla1, Kelvin Idanwekhai1,2, Martin Naradikian3

  • 1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, United States.

Journal of chemical information and modeling
|April 18, 2024
PubMed
概括

这项研究引入了一种机器学习方法,使用AlphaFold蛋白质结构来预测遗传变异如何影响生物途径. 该方法准确地识别了影响NRF2和c-Myc转录活动的关键蛋白质区域.

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