挪威中部的肠道聚合性大肠杆菌:一个前性,病例控制研究
Ingvild Haugan1,2, Marit Gudrun Husby1, Bjørg Skjøtskift1
1Department of Medical Microbiology, Clinic of Laboratory Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
PloS one
|April 18, 2024
概括
肠道聚合性大肠杆菌 (EAEC) 经常在腹患者中检测到,特别是那些最近国际旅行的患者. 国内EAEC与腹无关,EAEC阳性病例通常涉及并发感染.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 分子方法提高了便样本中的肠聚合性大肠杆菌 (EAEC) 检测.
- 关于EAEC检测的临床相关性仍在争论中.
- 这项研究旨在确定EAEC在腹患者和对照患者的流行率和特征.
研究的目的:
- 调查腹患者和健康对照患者中EAEC的流行率.
- 确定与EAEC感染相关的人口和旅行相关因素.
- 评估EAEC与其他肠道病原体的关联.
主要方法:
- 来自腹患者和健康对照者的便样本的前性研究 (2017年3月至2019年2月).
- 实时多重PCR用于病原体检测.
- 统计分析包括皮尔森奇平方,克鲁斯卡尔-沃利斯和曼-惠特尼U测试.
主要成果:
- 在4.6%的腹患者和2.2%的对照中检测到EAEC.
- 旅行者中腹的患病率为19.1%,非旅行者的患病率为2.2%.
- 在64.3%的EAEC阳性腹患者中发现了同时存在的病原体;EAEC阳性患者更年轻,更有可能旅行.
结论:
- 在腹患者中EAEC是常见的,特别是在最近的国际旅行中.
- 在国内获得的EAEC不太可能引起腹.
- 同时感染的EAEC阳性腹与年轻的年龄和旅行史有关.
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