患有感染相关急性脑病变的儿童的潜在疾病
Tomohiko Nakata1, Jun Natsume2, Hiroyuki Yamamoto1
1Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Pediatric neurology
|April 18, 2024
概括
患有下皮层扩散减少的急性脑病变 (AED) 的儿童往往有潜在的发作障碍或早产. 这些因素增加了发展AED的风险,突出了对这些儿科患者的谨慎需要.
科学领域:
- 儿科神经学 儿科神经学
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
背景情况:
- 儿童感染相关的急性脑病变 (AE) 由各种因素引起,包括传染病原体和慢性疾病.
- 识别导致潜在疾病的倾向对于理解AE发展至关重要.
研究的目的:
- 调查和比较被诊断患有两种AE的儿童的潜在疾病:降低皮下扩散 (AED) 的AE和具有可逆病变 (MERS) 的临床轻度脑病变.
- 通过将它们与急性扩散性脑炎 (ADEM) 进行比较来确定AED和MERS的特定易感因素.
主要方法:
- 日本东海地区患者数据的回顾性分析 (2009-2022年).
- 包括204名患有AED的患者,137名患有MERS的患者和89名患有ADEM的患者.
- 在三组中比较潜在疾病和过去的病史.
主要成果:
- 与ADEM (12%) 相比,AED病例显示潜在疾病的患病率显著更高 (34%).
- 在AED和MERS的潜在疾病包括发作,早产,遗传/先天性疾病和内分泌/脏疾病.
- 特定的综合征,如德拉维特和韦斯特综合征在AED中普遍存在,但在MERS中不存在;早产也在AED中更为常见.
结论:
- 发作易感性,特别是在慢性发作疾病中,是AED的重要诱导因素.
- 过早分娩也被认为是AED发展的重要因素.
- 建议对患有慢性发作疾病或早产的儿童进行临床警,因为他们患AE的风险增加.
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