母亲暴露于环境臭氧和胎儿心脏缺陷在中国:一个多中心队列研究
Yanping Ruan1, Yaqi Wang2, Jianhui Guo2
1Department of Echocardiography, Maternal-Fetal Medicine Research Consultation Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Ecotoxicology and environmental safety
|April 18, 2024
概括
孕妇在怀孕期间暴露于臭氧 (O3),特别是在产周期,显著增加胎儿心脏缺陷 (CTD) 的风险. 这项研究强调了空气污染对先天性心脏病发展的影响.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 心血管病理学心血管病理学
背景情况:
- 冠状动脉心脏缺陷 (CTD) 是先天性心脏病的一个重要问题.
- 虽然研究了母性因素,但特定的环境暴露,如臭氧 (O3) 对CTD风险的影响仍未得到充分研究.
研究的目的:
- 调查母亲暴露于环境臭氧 (O3) 与中国人口中CTD风险之间的关联.
- 确定怀孕期间O3暴露和CTD发展的临界暴露窗口.
主要方法:
- 一项在北京 (2013-2021) 进行胎儿心声扫描的孕妇队列研究.
- 根据怀孕关键时期 (胚胎,第一季度,周产期) 的住所地址,估计了母亲的O3暴露.
- 调整后勤回归模型分析了O3四分位数/度增加和CTD发生之间的关联.
主要成果:
- 总共有24,278名受试者被分析,其中有1069例CTD.
- 孕产妇在产前期的O3暴露与CTD风险增加显著相关 (OR=1.271每10μg/m3增加).
- 增加O3暴露的四分位数,特别是在围产期,显示了剂量-反应关系与更高的CTD风险.
结论:
- 在怀孕期间,尤其是围产期,母亲暴露于环境臭氧的增加是胎儿CTD的危险因素.
- 研究结果表明,需要制定公共卫生策略,以减轻怀孕期间O3暴露.
- 建议进行进一步的研究,包括纵向研究,以证实这些关联.
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