血清脑衍生神经营养因子,Val66Met多态性和开放标签SSRI治疗响应在严重抑郁症中
Anna J T Smit1, Gwyneth W Y Wu1, Ryan Rampersaud1
1Weill Institute for Neurosciences and Department of Psychiatry and Behavioral Sciences, University of California San Francisco (UCSF) School of Medicine, San Francisco, CA, USA.
Psychoneuroendocrinology
|April 18, 2024
概括
血清BDNF水平不能可靠地预测重大抑郁障碍 (MDD) 的抗抑郁药物反应. 虽然MDD患者的BDNF基线较高,但这与治疗结果或BDNF Val66Met多态性无关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 大脑衍生神经营养因子 (BDNF) 涉及抗抑郁药的作用和主要抑郁症 (MDD) 的病理生理学.
- 关于MDD中外围BDNF水平及其对抗抑郁药物反应的预测价值的先前研究产生了相互矛盾的结果.
- 这项研究研究了血清BDNF,BDNF Val66Met多态性和MDD中SSRI治疗反应之间的关联.
研究的目的:
- 调查MDD患者血清BDNF水平与SSRI治疗反应之间的关联.
- 探索BDNF Val66Met多态性 (rs6265) 在预测抗抑郁药治疗结果中的作用.
- 为了比较MDD患者和健康对照者的血清BDNF水平,并评估SSRI治疗期间的变化.
主要方法:
- 一项开放的临床试验,涉及99名无药MDD参与者和70名健康对照.
- 在53名MDD参与者中,血清BDNF水平和抑郁症评级 (HDRS) 在基线和8周SSRI治疗后被测量.
- 血清BDNF水平和MDD患者与Val66Met多态 (Met载体) 和Val/Val同位素之间的治疗反应的比较.
主要成果:
- 基线血清BDNF水平在未服用药物的MDD参与者中明显高于对照组,特别是在女性中.
- 基线血清BDNF水平与治疗反应或抑郁症评级的变化无关.
- 与Met载体相比,对Val等位基 (Val/Val) 具有同胞性MDD患者的抗抑郁药反应显著增加.
结论:
- 周围的BDNF水平对于表征抑郁或预测抗抑郁药物反应具有有限的诊断或预后效用.
- 性在缓解抑郁症BDNF差异中的作用需要进一步调查.
- 虽然中枢神经系统BDNF对于抗抑郁药的有效性至关重要,但它的血清水平在临床上具有有限的效用.
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