多克索鲁比和美特福林联合治疗的协同抗癌效应:一个系统的审查
Fereshtehsadat Jalali1, Fatemeh Fakhari2, Afrah Sepehr3
1Department of Obstetrics and Gynecology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
将多克索鲁比与甲胺结合使用,显示出强大的抗癌作用,克服药物耐药性. 这种协同疗法显著抑制了癌细胞的生长,并在临床前研究中改善了生存率.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 癌症研究 癌症研究
背景情况:
- doxorubicin (DOX) 是一种化疗剂,经常与获得的癌细胞耐药性有关.
- 新出现的证据表明,在癌症治疗中,甲福明和多克索鲁比辛之间存在协同作用的潜力.
研究的目的:
- 探索多克索鲁比和甲胺在各种癌症类型中的联合治疗效果.
- 评估这种组合治疗在克服耐药性的有效性.
主要方法:
- 在多个数据库 (Embase,Scopus,Web of Science,PubMed,Science Direct,Google Scholar) 根据PRISMA指南进行了全面的文献搜索,直到2023年7月.
- 搜索术语被精心挑选,以与研究目标保持一致.
- 经过严格的选,总共包括了30篇相关文章.
主要成果:
- 与单独治疗相比,多克索鲁比辛和甲胺的组合表现出更高的抗癌活性.
- 在体外研究证实了癌细胞增殖的显著抑制和增强的亡.
- 活体研究表明,瘤生长显著减少,生存率有所改善,突出显示了协同效应.
结论:
- doxorubicin 和美特福林的同时使用是癌症治疗的有希望的策略.
- 这种组合治疗显示出克服药物耐药性和改善患者结果的潜力.
- 进一步的临床研究是有必要的,以验证和优化多克索鲁比辛 - 甲福林治疗方案.
更多相关视频
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
相关概念视频
Oral Hypoglycemic Agents: Biguanides and Glitazones
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
