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Updated: Jun 28, 2025

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探索含有烯胺的环胺作为LSD1抑制剂:设计,合成,ADMET,MD分析和抗癌活性分析

Khursheed Ahmad Sheikh1, Darakhshan Parveen1, M Mumtaz Alam1

  • 1Drug Design and Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi 110062, India.

Bioorganic chemistry
|April 18, 2024
PubMed
概括

研究人员设计了具有抗癌性能的新皮里米丁衍生物. 三种化合物 (VIIb,VIIi,VIIm) 对各种癌细胞系表现出强烈的抗癌活性,并抑制了LSD1,提供了有前途的治疗途径.

关键词:
这是一种抗癌药物.环烯胺 是一种环胺.氨酸特异性脱甲基酶1 (LSD1) 是一种分子动力学模拟模型皮里米丁是什么 皮里米丁是什么

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