Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

243
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
243
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

1.9K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
1.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A neuron-glia circuit anticipates hypoxia to regulate organismal oxygen use.

bioRxiv : the preprint server for biology·2026
Same author

TARPγ2-Derived Peptide Enhances Early-Phase Long-Term Potentiation and Impairs Memory Retention in Male Rats.

Brain sciences·2025
Same author

Pupil size modulation drives retinal activity in mice and shapes human perception.

Nature communications·2025
Same author

Parvalbumin expression identifies subicular principal cells with high projection specificity.

Cell reports·2025
Same author

Deep mining in the dorsal raphe: cholecystokinin-expressing neurons encode satiation-related cues to regulate meal size.

Signal transduction and targeted therapy·2025
Same author

Sleep stages antagonistically modulate reactivation drift.

Neuron·2025

相关实验视频

Updated: Jun 28, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.6K

河马胆囊托基宁表达性内部神经元调节时间编码和上下文学习.

Dámaris K Rangel Guerrero1, Kira Balueva2, Uladzislau Barayeu1

  • 1Information and Systems Sciences, Institute of Science and Technology Austria, 3400 Klosterneuburg, Austria.

Neuron
|April 18, 2024
PubMed
概括

在小鼠中静止胆囊托基宁表达内神经元 (CCKI) 破坏了位置细胞时代编码,但增强了上下文记忆回忆. CCKI是记忆形成和神经网络调节的关键.

关键词:
在CA1 CCK内部神经元中.在GABAergic调制过程中.化学遗传学 化学遗传学记忆 记忆 记忆 记忆 记忆视觉遗传学 视觉遗传学振荡的振荡是如何发生的放置细胞的编码.尖的波浪波的波浪.泰达阶段的前行阶段.轨道重复播放 轨道重复播放

更多相关视频

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons
14:37

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons

Published on: September 30, 2014

24.5K
Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope
07:00

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope

Published on: August 2, 2024

1.5K

相关实验视频

Last Updated: Jun 28, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.6K
Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons
14:37

Whole-cell Patch-clamp Recordings from Morphologically- and Neurochemically-identified Hippocampal Interneurons

Published on: September 30, 2014

24.5K
Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope
07:00

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope

Published on: August 2, 2024

1.5K

科学领域:

  • 神经科学是一个神经科学.
  • 细胞神经科学 细胞神经科学
  • 系统神经科学 系统神经科学

背景情况:

  • 胆囊托基因因表达性内部神经元 (CCKI) 参与调节神经网络活动和金字塔细胞发射模式.
  • 它们在海马体CA1网络动态和记忆中的确切作用仍然不完全理解.

研究的目的:

  • 为了研究CCKIs在海马CA1区域的功能作用.
  • 确定CCKI活动对金字塔细胞发射,网络振荡和记忆过程的影响.

主要方法:

  • 在小鼠中对CCKI进行光遗传和化学遗传沉默.
  • 电生理学记录以评估网络活动和细胞点火模式.
  • 包括莫里斯水迷宫和情境恐惧条件化的行为范式.

主要成果:

  • 光遗传CCKI沉默揭示了异质的内部神经元群体,并诱导了广泛的抑制.
  • CCKI静音增强了金字塔细胞爆发发射,并扰乱了位细胞中的甲基相前行.
  • 序列重新激活得到增强,化学遗传沉默改善了情境恐惧记忆回忆和歧视.

结论:

  • CCKI在调节海马体内的位置细胞的时间编码方面发挥着至关重要的作用.
  • CCKI对于整合和回忆上下文记忆至关重要.
  • 针对CCKI可能为与记忆有关的疾病提供治疗潜力.