术前血清度和口腔癌患者的疾病特异性生存率:长期随访研究
Xiaodan Bao1, Fa Chen2, Fengqiong Liu2
1Assistant Experimentalist, School of Health Management, Fujian Medical University, Fuzhou, Fujian, China.
概括
较高的血清 (Se) 水平与口腔癌患者的疾病特异性生存率 (DSS) 的改善有关. 这种效应在与放射治疗治疗相结合时特别明显.
科学领域:
- 在瘤学瘤学.
- 营养生物化学 营养生物化学
- 流行病学 流行病学
背景情况:
- 血清 (Se) 度与口腔癌发病率有关.
- 血清Se对口腔癌患者的长期生存的影响尚不清楚.
研究的目的:
- 在口腔癌患者中研究术前血清Se度与疾病特异性存活率 (DSS) 之间的关联.
主要方法:
- 这是一项前性队列研究,涉及235名新诊断初级口腔癌患者.
- 使用感应合的血质谱法测量血清Se水平.
- 使用Kaplan-Meier,Cox回归和受限立方线模型分析的疾病特异性生存率 (DSS).
主要成果:
- 较高的血清Se水平与改善的DSS有关,无论是未调整的 (HR=0.70) 还是调整的 (aHR=0.67).
- 在Se和放射治疗之间观察到显著的相互作用,较高的Se水平增强了放射治疗对生存的保护作用 (aHR=0.36).
- 只有接受放射治疗的患者 (aHR=0.49) 才有显著的Se和DSS之间的关联.
结论:
- 血清Se度升高可能有助于改善口腔癌患者的DSS.
- 似乎Se对生存的有益影响部分是由放射治疗介导的.
- 需要进一步的研究来探索Se的作用及其与放射治疗在口腔癌预后中的相互作用.
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