缓解微囊素-氨酸-氨酸诱导的肝毒性:一个更新的概述
Habibeh Mashayekhi-Sardoo1, Ramin Rezaee2, Bamdad Riahi-Zanjani3
1Bio Environmental Health Hazard Research Center, Jiroft University of Medical Sciences, Jiroft, Iran; Jiroft University of Medical Sciences, Jiroft, Iran.
概括
来自蓝绿藻的微囊素-氨酸氨酸 (MC-LR) 会导致肝脏损伤. 临床前研究表明,草药衍生物,补充剂和药物可以通过阻断毒素吸收和恢复酶活性来防止MC-LR肝毒性.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 地表水被蓝绿藻污染对健康构成重大风险.
- 微囊 (MCs),特别是微囊-氨酸-氨酸 (MC-LR),是由微囊 (Microcystis aeruginosa) 生产的强有力的肝毒素.
- 通过进入肝细胞并抑制关键蛋白质酸酶,MC-LR会导致肝毒性.
研究的目的:
- 对MC-LR诱导的肝毒性治疗方法的临床前研究进行审查.
- 为了确定可以减轻MC-LR的毒性作用的药物.
主要方法:
- 在主要的科学数据库 (Web of Science,Embase,Medline,Scopus,Google Scholar) 进行了全面的文献搜索,截至2023年11月.
- 相关的关键词被用于识别检查干预措施对抗MC-LR肝毒性的临床前研究.
主要成果:
- MC-LR通过有机阴离子转运多 (OATP) 载体进入肝细胞,并抑制蛋白酸酶 (PP1和PP2A).
- 这种抑制会破坏信号通路,诱导氧化应激,并损害细胞大分子.
- 一些药物,包括富含黄胺的植物,天然补充剂和化学保护剂,在减少MC-LR肝毒性方面表现出有效性.
结论:
- 通过多种机制观察到对MC-LR的肝保护作用.
- 像纳林金,卡普托普利和西利马林这样的药物有效地阻断了OATP载体,抑制了MC-LR的吸收,并恢复了蛋白质酸酶的活性.
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