严重患病的COVID-19易感基因CCR3显示了撒哈拉以南非洲人的自然选择
Zewen Sun1, Lin Pan2, Aowen Tian3
1Department of Genetics, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.
概括
自然选择导致撒哈拉以南非洲人增加了CCR3表达,为关键的COVID-19提供了抵抗力. 这表明CCR3是严重COVID-19的潜在治疗点.
科学领域:
- 遗传学 是一个遗传学.
- 进化生物学 进化生物学
- 免疫学 免疫学 免疫学
背景情况:
- 在不同种族之间,COVID-19危急疾病的患病率有所不同.
- 人们怀疑遗传因素会影响这种变异.
- 撒哈拉以南非洲人对严重的COVID-19具有不同的易感性.
研究的目的:
- 在撒哈拉以南非洲人中调查与关键COVID-19相关的基因中的自然选择信号.
- 确定COVID-19严重程度变化的潜在遗传机制.
- 探索CCR3作为潜在的治疗点.
主要方法:
- 来自HGI的严重COVID-19单核酸多形态 (SNP) 的分析.
- 在661名撒哈拉以南非洲人群中,使用集成的单双型得分 (iHS),跨种群扩展单双型同胞性 (XP-EHH) 和固定指数 (Fst) 评估选择信号.
- 古代DNA和门德尔随机化的等位基因频率轨迹分析.
主要成果:
- 在撒哈拉以南非洲人中发现了CCR3基因显著的自然选择信号.
- 这种CR3变异rs17217831-A显示出强烈的选择信号 (高iHS和XP-EHH).
- 自然选择增加了CCR3的表达,这种表达,与乙氨基酸细胞计数一起,与危急COVID-19的风险降低有关.
结论:
- 撒哈拉以南非洲人由于进化选择而表现出对关键的COVID-19的自然抵抗力.
- CCR3被确定为正在选择的关键基因,影响COVID-19的严重程度.
- CCR3为缓解严重的COVID-19结果提供了一个潜在的新型治疗标.
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