单次服用一种迷幻药物[R) -DOI]会影响应对应对可逃脱的社会压力的策略
Kevin T Krupp1, Jazmine D W Yaeger2, Leighton J Ledesma3
1Department of Biology, University of South Dakota, Vermillion, SD, 57069, USA; Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA.
Neuropharmacology
|April 18, 2024
概括
迷幻化合物 (R) -DOI通过降低瘤死因子-α (TNFα) 等炎症标志物来减少小鼠的压力行为和焦虑. 这表明,对于与压力相关的疾病,有潜在的治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 免疫学 免疫学 免疫学
背景情况:
- 迷幻化合物显示出快速,持久的抗焦虑,抗抑郁和抗炎作用的承诺.
- 小鼠的社会侵略模型显示出不同的炎症反应和应对压力的行为 (Stay vs. 逃跑) 的意思.
- 瘤亡因子-α (TNFα) 是一种炎症性细胞因子,与应激反应有关.
研究的目的:
- 为了调查精神迷幻 (R) -2,5-dimethoxy-4-iodoamphetamine [(R) -DOI],一个5-HT2A受体激动剂,是否可以减少与压力相关的小鼠行为.
- 探索 (R) -DOI的行为影响与其潜在的抗炎性质之间的联系.
主要方法:
- 雄性小鼠被暴露在压力替代模型 (SAM) 中,这是一个可以逃脱的社会压力范式.
- 根据动物的应对策略,动物被分为"停留" (易受压力) 或"逃跑" (抗压) 组.
- 小鼠接受一次 (R) -DOI的低剂量,并评估行为变化,血和神经TNFα水平.
主要成果:
- "停留"小鼠表现出较高的细胞因子基因表达,而"停留"和"逃跑"组与对照组相比显示TNFα水平升高.
- (R) -DOI的管理使"停留"小鼠转向更积极的应对,增加逃跑行为和减少结.
- (R) -DOI治疗降低了"停留"小鼠的血和大脑TNFα水平,与行为改善相关.
结论:
- 在社会侵略模型中, (R) -DOI通过促进积极的应对压力行为来表现出类似焦虑缓解的效果.
- (R) -DOI的抗焦虑作用与炎症性细胞因子TNFα的减少有关.
- 这些发现表明, (R) -DOI可能通过调节神经炎症来发挥其治疗作用.
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