在紧急腹部拉皮切除术/视镜中进行个性化PeriopeRative开放肺部VEntilatory方法的推理和研究设计:为潜在的国际随机对照试验的研究协议
G Laguna1, F Suárez-Sipmann2, G Tusman3
1Departamento de Anestesia y Cuidados Críticos, Hospital Clínic, Barcelona, España.
Revista espanola de anestesiologia y reanimacion
|April 18, 2024
概括
这项研究将个性化的外科手术开放肺部方法 (OLA) 与紧急腹部手术的标准肺部保护性通风进行比较. 它调查了OLA是否可以减少肺缩患者手术后肺部并发症 (PPC).
科学领域:
- 麻醉学和重症监护医学
- 呼吸系统医学 呼吸系统医学
- 手术创新 在外科创新.
背景情况:
- 手术后的肺部并发症 (PPC) 是常见的,影响20-40%的手术患者.
- 在紧急腹部手术中PPC的患病率还没有得到很好的定义.
- 肺保护性通风和开放式肺方法 (OLA) 旨在减少PPC,但证据尚不确定.
研究的目的:
- 为了比较个性化外科手术期间的OLA与传统的肺保护性通风.
- 评估OLA在预防PPC患者的疗效,这些患者接受了急诊腹部手术,手术内肺缩.
主要方法:
- 国际随机临床试验 (iPROVE-EAL) 将个性化的OLA与传统的肺保护性通风进行比较.
- 经过紧急腹部手术的肺缩临床症状的患者被随机分类.
- 主要结局:严重的PPC在7天内 (急性呼吸衰竭,肺胸,断奶失败,ARDS,肺部感染).
主要成果:
- N/A - 结果没有在摘要中提供.
结论:
- 该iPROVE-EAL试验是第一个在紧急外科手术中调查个性化外科手术期间OLA用于PPC预防的试验.
- 为了确定该策略的有效性,正在等待进一步的结果.
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