美国成年人暴露于挥发性有机化合物和死亡率:基于人口的前性队列研究
Xiaobing Feng1, Feng Qiu2, Ling Zheng1
1Department of Medical Records Statistics, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430016, China.
易挥发性有机化合物 (VOCs) 暴露与死亡风险增加有关. 减少VOC可以显著降低所有原因,心血管,呼吸道和癌症疾病的死亡率.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 挥发性有机化合物 (VOC) 是普遍存在的环境污染物.
- 有限证据表明,与VOC联合暴露相关的死亡风险有限.
研究的目的:
- 调查个人和联合VOC暴露与所有原因和特定原因死亡率之间的关联.
- 量化可归因于VOC暴露的死亡负担.
主要方法:
- 利用国家健康和营养检查调查 (NHANES) 数据 (2005-2018) 随着死亡率的随访.
- 通过尿路代谢物测量了12个VOC,并计算了联合暴露的环境风险评分 (ERS).
- 采用Cox的比例危险和受限制的立方螺纹模型来评估死亡风险.
主要成果:
- 在特定的VOC (亚克罗莱因,烯,1,3-丁,乙/烯) 和死亡率之间发现了显著的线性剂量反应关系.
- 增加的ERS与所有原因,心血管疾病 (CVD),呼吸系统疾病 (RD) 和癌症死亡率的风险更高有关.
- 联合VOC暴露占死亡的很大一部分:17.95%是所有原因,13.49%是心血管疾病,35.65%是RD,33.85%是癌症.
结论:
- 个人和联合VOC暴露显著增加了所有原因和特定原因死亡的风险.
- 减少环境中的VOC暴露可能会大大降低各种疾病的死亡负担.
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