为什么 perfluorocarbon纳米粒子在临床翻译中遇到瓶,尽管有希望的氧气载体?
Anindita De1, Jun-Pil Jee2, Young-Joon Park3
1College of Pharmacy, Ajou University, 206 Worldcup-ro , Yeongtong-gu, Suwon-si 16499, Republic of Korea.
概括
人工氧气载体 (AOCs) 显示出希望,但在临床试验中面临挑战. 未来的成功取决于高碳 (PFC) 纳米粒子的先进配方和精心设计的试验.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
背景情况:
- 人工氧气载体 (AOC),特别是基于碳 (PFC) 的载体,已经被探索了几十年.
- 尽管自20世纪80年代以来进行了大量的临床试验,但PFC纳米颗粒的成功却有限.
- 挑战包括副作用,复杂的配方和不足的试验设计.
研究的目的:
- 审查PFC化合物的临床试验.
- 确定限制PFC纳米颗粒成功的因素.
- 为成功发展AOC提出未来的战略.
主要方法:
- 基于PFC的AOC临床试验的综合文献综述.
- 分析导致试验失败的因素.
- 讨论不同的PFC配方世代及其局限性.
主要成果:
- 在临床转化中,PFC纳米颗粒面临着重大障碍.
- 药理学副作用和配方复杂性是关键问题.
- 过去的临床试验设计往往不足.
结论:
- 需要先进的,生物相容的,单成分配方用于AOC.
- 新型药物输送系统,如凝或逆乳液,显示出潜在的潜力.
- 精心策划的临床试验对于基于PFC的AOC的未来成功至关重要.
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