早期的逆境与成年大脑中预期值信号的降低有关
Seda Sacu1, Magda Dubois2, Frank H Hezemans3
1Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; German Center for Mental Health, Mannheim, Heidelberg, and Ulm, Germany.
Biological psychiatry
|April 18, 2024
概括
早期的逆境,尤其是母亲的低刺激,会扰乱成年人的奖励学习,影响对决策至关重要的大脑区域,增加精神病理的风险. 这种长期影响凸显了早期经历对心理健康的持久影响.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 计算精神病学是一种计算精神病学.
背景情况:
- 早期的不良经历被假设会影响奖励学习和决策过程.
- 对这些影响的计算神经成像研究是有限的,特别是对于成年人群的长期后果.
研究的目的:
- 调查早期生活逆境和奖励学习的计算标记之间的长期关联.
- 为了检查成年大脑奖励网络中这些关联的神经相关性.
- 探索逆境,奖励学习和精神病理学之间的联系.
主要方法:
- 长度出生队列研究,包括156名参与者,年龄在33岁时进行评估.
- 在被动回避任务期间的功能磁共振成像 (fMRI).
- 7个逆境指标的主要组成部分分析;多重回归分析将逆境因素与精神病理和神经反应联系起来.
主要成果:
- 较低的母体刺激与右门,右核和前带皮层的预期值表示率降低有关.
- 在右侧的核中减少的预期值编码调解了这种逆境维度和精神病理之间的联系.
- 这种逆境维度预测在COVID-19大流行期间增加了戒断症状.
结论:
- 早期的不良经历,特别是在护理人员的背景下,可以持续地破坏关键大脑区域的奖励学习.
- 这种干扰可能会导致低于最佳的决策,并增加发展精神病理的风险.
- 这些发现强调了早期生活逆境对成人神经生物学和心理健康的持久影响.
相关概念视频
Attention-Deficit/Hyperactivity Disorder
57
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
57
Adler's Individual Psychology
664
Alfred Adler, a prominent figure in psychology, founded the school of individual psychology. In contrast to Freud's emphasis on sexual or aggressive motives, Adler suggested that individuals are primarily motivated by their purposes and goals. He believed that people strive for perfection rather than pleasure. Adler argued that individuals could creatively act upon their genetic inheritance and environmental experiences to shape their own lives, emphasizing conscious motivation over...
664
Emerging Adulthood
60
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
60
Cognitive Development During Adulthood
94
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
94
Cognitive Development During Adolescence
54
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
54


