对空气污染相关心血管疾病的新见解:PM2.5相关的血管化的一个不良结果路径框架
Ruiyang Ding1,2, Linyuan Huang1,2, Kanglin Yan1,2
1Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing 100069, PR China.
Cardiovascular research
|April 18, 2024
概括
细颗粒物 (PM2.5) 暴露会通过氧化应激和炎症导致血管化. 本综述概述了将PM2.5与心血管疾病联系起来的不良结果途径 (AOP),确定了关键事件和生物标志物.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管科学 心血管科学
背景情况:
- 环境细颗粒物 (PM2.5) 污染是严重的公共卫生威胁.
- 与心血管疾病相关的血管化越来越多地与PM2.5暴露有关.
- 在PM2.5引起的血管化背后的精确机制需要阐明.
研究的目的:
- 审查和解释有关PM2.5和血管化的现有毒理学和流行病学发现.
- 为PM2.5相关的血管化提出一个全面的不良结果途径 (AOP) 框架.
- 识别知识缺口和未来研究的潜在生物标志物.
主要方法:
- 综合毒理学和流行病学数据的文献综述.
- 应用不良结果路径 (AOP) 概念.
- 识别分子启动事件 (MIE) 和关键事件 (KE).
主要成果:
- 反应性氧物种的产生被确定为MIE.
- 关键事件包括氧化应激,炎症,内质网膜应激和自.
- 这些事件最终导致血管化和动脉样硬化.
结论:
- 拟议的AOP框架提供了对PM2.5在血管化中的作用的机制性理解.
- 这个框架强调氧化应激和炎症是关键途径.
- 该研究确定了未来对PM2.5相关心血管风险的研究的局限性和潜在生物标志物.
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