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酸盐暴露和冠心病:氧化应激和改变miRNA表达的可能影响
Asmaa Mohammad Moawad1, Sara Awady1, Abla Abd El Rahman Ali1
1Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Kasr Alainy Street, Cairo 11562, Egypt.
Chemical research in toxicology
|April 18, 2024
概括
通过尿液单-2-乙基基甲酸盐 (MEHP) 测量的甲酸盐暴露与冠状动脉心脏病 (CHD) 有关. 氧化应激和改变的微RNA (miRNA) 表达可能解释了这种关联.
科学领域:
- 环境健康 环境健康
- 心血管疾病研究研究
- 分子生物学分子生物学
背景情况:
- 酸盐暴露与冠心病 (CHD) 之间的联系仍然不完全理解.
- 酸盐是常见的环境化学物质,具有潜在的内分泌干扰特性.
- 调查甲酸盐诱导心血管风险背后的机制至关重要.
研究的目的:
- 检查甲酸盐暴露与心脏病之间的关联.
- 探索涉及氧化应激和microRNA (miRNA) 表达的潜在的有机性途径.
- 为了将尿液中的单-2-乙基基甲酸盐 (MEHP) 水平与氧化应激标志物和特定的miRNA相关联.
主要方法:
- 一项涉及110名参与者的病例控制研究 (55名患有心脏病,55名健康对照).
- 测量尿中的MEHP,氧化应激标记物 (氨酸化物[MDA]和超氧化物脱酶[SOD]),以及miRNA-155 (miR-155) 和miRNA-208a (miR-208a) 的表达.
- 使用斯皮尔曼相关性来评估变量之间的关系的统计分析.
主要成果:
- 在心脏病患者和对照组之间观察到MEHP,MDA,SOD,miR-155和miR-208a的显著差异 (p < 0.001).
- 在尿路MEHP和MDA (rs = 0.316,P = 0.001) 和miR-155 (rs = 0.318,P = 0.001) 之间发现了正相关性.
- 在尿路MEHP和SOD (rs = -0.345,P < 0.001) 和miR-208a (rs = -0.352,P < 0.001) 之间发现了负相关性.
结论:
- 尿中MEHP水平与心脏病有关.
- 甲酸盐暴露可能通过涉及氧化应激和改变miR-155和miR-208a表达的机制导致心血管疾病.
- 这些发现突出了潜在的分子通路,将环境甲酸盐与心血管疾病联系起来.
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