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血中乙氨基酸细胞数量与FEV₁下降的关联:一个队列研究

Yun Soo Hong^1,2,3, Hye Yun Park^4,3, Seungho Ryu^5,6,7

¹McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

The European respiratory journal

|April 18, 2024

概括

血中乙氨基酸细胞数量较高与健康成年人肺功能下降的速度较快有关,即使在非吸烟者中也是如此. 这表明,乙素可能是呼吸系统健康风险的早期指标.

科学领域:

肺部医学肺部医学
免疫学免疫学免疫学
流行病学流行病学

背景情况:

加快的肺功能下降是慢性阻塞性肺病 (COPD) 的标志.
鉴于吸烟状况,年轻,健康个体的血中乙氨基酸水平和肺功能下降之间的关系需要进一步调查.

研究的目的:

为了研究血中原氨基酸基数和没有流行肺病的成年人肺功能下降的速度之间的关联.
要确定这种关联是否独立于吸烟状态.

主要方法:

对629,784名韩国成年人进行了一项大型队列研究,他们以前没有COPD或喘.
使用线性混合效应模型分析每年1秒强迫呼气体积的变化 (FEV1),调整吸烟状态和其他共变量.
基于基线和时间变化的吸烟状态进行了分层分析.

主要成果:

观察到血液中较高的乙氨基酸细胞数量与FEV1.1的年度下降速度较快之间存在统计学上显著的关联.
对于具有≥500个细胞·μL-1的埃索诺菲尔人群,FEV1的下降为-26.8毫升/年,而<100个细胞·μL-1.1的人群的FEV1下降为-23.3毫升/年.
这种与更高的乙氨基酸细胞数量相关的肺功能加速下降在从未吸烟者和经常吸烟者中是一致的,并且在考虑时间变化的吸烟状态时持续存在.

结论:

血中乙氨基酸细胞数量的升高独立地与没有先前存在的肺部疾病的个体的加速肺功能下降有关.
这些发现表明,血中乙氨基酸细胞数量可能作为肺功能下降的预测生物标志物,即使没有被诊断的呼吸道疾病.
这些结果突出显示了氨基酸在肺功能障碍早期发病的潜在作用,特别是在年轻人中.

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