是有益微生物产生的生物活性化合物
L Crespo1, B Sede Lucena2, F G Martínez1
1Centro de Referencia para Lactobacilos (CERELA)-CONICET, San Miguel de Tucumán, Argentina.
Advances in applied microbiology
|April 18, 2024
概括
(Se) 是一种对人类健康至关重要的微量元素,缺陷影响全球数以百万计的人. 利用Se丰富的细菌和纳米颗粒提供了一种安全和生物可利用的方法,可以提高饮食中的Se摄入量,并对抗与缺乏相关的疾病.
科学领域:
- 生物化学与人类健康
- 环境科学和微生物学
- 食品科学与营养 食品科学与营养
背景情况:
- (Se) 是一种重要的微量元素,是参与人类甲状腺代谢和氧化还原平衡的蛋白质的组成部分.
- 全球500-1000万人受到Se缺乏的影响,这与感染和慢性疾病 (如癌症和神经退行性疾病) 的易感性增加有关.
- 饮食中的Se摄入量受到土壤含量和生物可用性的影响,而Se分布存在显著的区域差异.
研究的目的:
- 探索细菌代谢及其对人类健康的影响.
- 研究纳米粒子 (SeNPs) 和丰富细菌在食品强化中的应用.
- 通过丰富食品和改善公共卫生来讨论对抗Se缺乏症的可持续策略.
主要方法:
- 对细菌的Se代谢和Se盐转化为Se氨基酸和SeNP等不那么有毒,生物可用的形式的审查.
- 一般被认为是安全的化微生物在制造化发酵和益生菌食品中的应用.
- 利用促进植物生长的细菌及其SeNP用于Se生物强化作物.
主要成果:
- 与Se盐相比,Se氨基酸和SeNP被确定为Se的最少毒性和最生物可用形式.
- 化微生物和SeNPs可以有效地用于食品强化和作物生物强化.
- 细菌的Se代谢为生产富含Se的食物提供了可持续的途径.
结论:
- 通过生物强化食品提高饮食中的Se状态是打击广泛存在的Se缺乏症的关键策略.
- 使用Se丰富的细菌和SeNPs是一种安全,可持续和有效的方法来改善人类的Se摄入量和健康结果.
- 对细菌Se代谢和应用的进一步研究对公共卫生干预有重大前景.
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