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Updated: Jun 29, 2026

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在老化和阿尔茨海默病模型小鼠大脑中识别衰老的,表达TREM2的微质

Noa Rachmian1,2, Sedi Medina2, Ulysse Cherqui1

  • 1Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

Nature neuroscience
|April 18, 2024
PubMed
概括

这项研究在阿尔茨海默氏病模型中确定了表达TREM2的衰老微质. 用ABT-737准这些衰老细胞改善了认知能力,并减少了大脑炎症.

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Alzheimer Disease ll: Pathophysiology01:23

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...