空间建模将儿童类皮肤炎的流行率与家庭对污染物的暴露联系起来
Grace Ratley1, Jordan Zeldin1, Ashleigh A Sun1
1Laboratory of Clinical Immunology and Microbiology, Epithelial Therapeutics Unit, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Communications medicine
|April 18, 2024
概括
空气污染和合成产品中的,,乙和 (BTEX) 化合物与亚托皮炎 (AD) 爆发有关. 这些化学物质破坏皮肤细菌并激活受体,这可能解释了AD的环境触发因素.
科学领域:
- 环境科学 环境科学
- 皮肤病学 皮肤病学
- 微生物学 微生物学
背景情况:
- 亚托皮炎 (AD) 是一种慢性炎症性皮肤疾病,在美国的流行率越来越高.
- 之前的研究表明,异酸盐空气污染和阿尔茨海默病之间存在联系,包括关于皮肤失生症和TRPA1激活的机械学数据.
- 非空间模型可能受到混因素的限制,并错过了其他环境关联.
研究的目的:
- 通过空间分析,研究特定空气污染物与亚托皮炎 (AD) 之间的关联.
- 检查儿童暴露于,,乙和 (BTEX) 相关产品及其与AD的相关性.
- 评估涉及的化合物和合成织物对皮肤共生细菌生长和新陈代谢的影响.
主要方法:
- 空间分析与污染数据和临床访问相结合,以确定环境关联.
- 一项追溯病例控制调查评估了儿童暴露在BTEX相关产品中的情况.
- 在体外研究中评估了纯化合物和合成织物的皮肤细菌的影响.
主要成果:
- 空间分析涉及BTEX化合物,特别是,在AD.
- 在暴露于烯衍生的聚床单和含有二酸盐的壁纸粘合剂时,发现了AD的显著概率比率.
- 合成织品促进了黄金葡萄球菌的生长,并改变了有益的皮肤共生者的新陈代谢,使它们远离治疗途径.
结论:
- 在原始和合成产品形式的BTEX化学品,为环境诱导的AD火焰提供了一个统一的假设.
- 这些化学物质通过引起皮肤微生物群失调并激活TRPA1受体来促进AD.
- 这些污染物的分布可能有助于在AD率中观察到的种族差异.
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