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英国严重的眼部化学伤害:英国眼科监测局的研究

Nicola Cronbach1, Barny Foot2, Richard Scawn3

  • 1Ophthalmology Department, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, UK. n.cronbach@nhs.net.

Eye (London, England)
|April 18, 2024
PubMed
概括

严重的眼部化学伤害很少见,但由于英国的袭击事件而增加. 大多数患者需要手术并经历长期并发症,突出需要有效的管理策略.

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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
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