慢性脏疾病和认知表现:NHANES 2011-2014 年份
Te Li1, Zhiling Hu2, Luyao Qiao3
1Department of Nephrology, Nanchang People's Hospital, Nanchang, Jiangxi, , China.
BMC geriatrics
|April 18, 2024
概括
慢性病 (CKD),特别是3-5阶段,与老年人认知功能较差有关. 建议对所有患有CKD的人进行早期认知障碍查.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年医学 老年医学
- 神经科学是一个神经科学.
背景情况:
- 现有研究表明慢性病 (CKD) 与认知障碍之间存在潜在联系.
- 了解这种关联对于管理老龄化人口的健康至关重要.
研究的目的:
- 调查老年美国成年人的CKD不同阶段和认知表现之间的关系.
- 在这个人口群体中确定受CKD影响的特定认知领域.
主要方法:
- 利用了2011-2014年国家健康和营养检查调查 (NHANES) 的数据.
- 采用多变量逻辑回归,子组分析和受限制的立方支线模型.
- 使用CERAD测试,动物流利性测试和数字符号替换测试 (DSST) 评估认知功能.
主要成果:
- 在CERAD,Animal Fluency和DSST测试中,在3-5阶段的CKD和较低的分数之间发现了显著的关联.
- 认知功能随着估计的淋巴细胞过率 (eGFR) 的下降而下降,在低和中等的eGFR水平下显着影响.
- 在eGFR和DSST/Animal Fluency分数之间观察到非线性剂量反应关系,而在CERAD分数中观察到线性关系.
结论:
- 慢性瘤,特别是3-5阶段,与执行功能,学习,处理速度,集中度和工作记忆的受损显著相关.
- 这些发现强调了认知查对所有被诊断为CKD的成年人的重要性.
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