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从人体扫描仪获得的47个人体标志物与基于人口的研究中的相对无脂肪质量之间的关联
Maximilian Dietzmann1, Dörte Radke1, Marcello Rp Markus2,3
1Institute for Community Medicine, University Medicine Greifswald, Walther Rathenau Str. 48, D-17475, Greifswald, Germany.
BMC public health
|April 18, 2024
概括
低脂肪无脂肪质量 (FFM) 增加疾病风险,但很难测量. 易于测量的身体周长,特别是部和腰部,可以作为FFM在临床环境中的实际替代品.
科学领域:
- 人体生理学 人体生理学
- 身体组成分析 身体成分分析
- 人类测量学 人类测量学.
背景情况:
- 低相对无脂肪质量 (FFM) 与慢性疾病和死亡风险增加有关.
- 目前测量FFM的方法在临床实践中没有常规使用,这阻碍了个性化治疗.
- 需要可访问的人类测量标记作为FFM评估的实际替代品.
研究的目的:
- 识别与FFM相关的易于访问的人类识别标记.
- 评估这些标志物的有用性,以估计FFM在一个庞大的基于人口的队列.
- 探索个性化患者治疗中的潜在应用.
主要方法:
- 分析了来自1593人的数据 (SHIP-TREND 1研究).
- 使用3D光学人体扫描仪推导47个人体标记.
- 通过生物电阻分析 (FFMBIA) 和空气位移充血图 (FFMADP) 来评估FFM.
- 性别分层线性回归模型用于评估人体测量标记和FFM之间的关联,调整为身高和年龄.
主要成果:
- 高部,腹部,中部,腰部和高腰部的周长显示出与FFM最强的反向关联.
- 这些关联在女性中比男性更明显.
- 人类测量标记显示,通过空气位移囊造影 (FFMADP) 评估的FFM与生物电阻分析 (FFMBIA) 评估的FFM的相关性更强.
结论:
- 某些人体测量指标,特别是部和腰围,可以作为FFM的有效替代品.
- 这些可访问的标记物可以通过提供评估FFM的实际手段来促进个性化治疗.
- 需要进一步的研究来探索全身强度 (作为FFM的替代品) 和脂肪质量之间的关系,因为鉴定到的标记物代表着内脏脂肪组织.
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