在垂体神经内分泌瘤中,panobinostat针对Nrf2的治疗潜力

Yijun Cheng1, Yuting Dai2, Hao Tang1

  • 1Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin er road, Shanghai, 200025, China.

概括

激素脱乙酶抑制剂 (HDACIs),特别是帕诺比诺斯塔特,显示出希望作为有效的药物疗法用于垂体瘤 (PitNETs). 将Panobinostat与Nrf2抑制剂结合使用,通过调节Nrf2信号来协同增强其抗PitNET作用.

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