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Updated: Jun 28, 2025

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通过多层次的in-silico方法识别新的强效NLRP3抑制剂

Chandni Hayat1, Vetriselvan Subramaniyan2,3, Mubarak A Alamri4

  • 1Department of Biochemistry, Abdul Wali Khan University, Mardan, Mardan, 23200, Pakistan.

BMC chemistry
|April 18, 2024
PubMed
概括

研究人员确定了六种稳定的NLRP3炎症酶抑制剂,用于潜在的糖尿病治疗. 这些化合物显示出开发新药的希望,通过阻断NLRP3激活来向炎症性疾病.

关键词:
糖尿病是一种糖尿病.在炎症中,一些细胞会发炎.抑制剂是一种抑制剂.在NLRP3中,NLRP3是NLRP3中的一个.药科类型的模型.

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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