系统性透皮迪克洛芬雅克贴片在腰椎手术后术后疼痛的有效性
Masato Uematsu1, Koji Tamai1, Hiroshi Hyakutake2
1Department of Orthopaedic Surgery, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Spine
|April 19, 2024
概括
通过皮肤注射的迪克洛芬雅克贴片 (DP) 在腰椎手术后有效降低了疼痛和阿片类药物使用. 这种迪克洛菲纳克贴片 (DP) 显示出安全性,特别是在不太侵袭的非融合手术中.
科学领域:
- 整形外科 整形外科 整形外科
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 有效的术后疼痛控制对于脊柱手术的良好结果至关重要.
- 多模式止痛策略可以帮助减少阿片类药物消费.
- 系统性透皮迪克洛芬雅克贴片 (DP) 正在探索,以立即缓解手术后的疼痛.
研究的目的:
- 评估全身透皮迪克洛芬雅克贴片 (DP) 在腰椎手术后术后止痛的疗效和安全性.
- 为了比较疼痛得分,止痛剂的需求,和患者接受DP和那些不之间的并发症.
主要方法:
- 一项前性,比较性研究,涉及224名接受后腰椎外科手术的患者.
- 患者被分为两组:那些接受DP治疗的人 (DP [+] 组) 和那些没有 (DP [-] 组).
- 收集的数据包括疼痛评分 (VAS),阿片类药物消费 (MME) 和并发症,并对融合与非融合程序进行亚组分析.
主要成果:
- 两组之间没有观察到功能恶化的显著差异.
- DP (+) 组在术后1小时内使用的救援止痛药较少 (P=0.046).
- 在非融合手术小组中,DP (+) 患者在1小时和3小时内有显著较低的MMEs,较少的救援止痛药和较低的VAS疼痛评分.
结论:
- 系统性透皮DP似乎是腰椎手术后术后止痛的安全有效选择.
- 在非融合外科手术等较少侵入性手术中,特别注意到DP的好处.
- 透皮迪克洛芬雅克贴片 (DP) 可能是脊髓外科手术中多模式疼痛管理策略的宝贵组成部分.
相关概念视频
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
430
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
430
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
623
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
623