在体外受精后出生的新生儿中,与普通人口中的新生儿相比,维生素D3
Karen Christina Walker1, Sofie Gry Pristed2,3, Fanney Thorsteinsdottir1,4
1Research Unit for Dietary Studies, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
Acta obstetricia et gynecologica Scandinavica
|April 19, 2024
概括
在体外受精 (IVF) 后出生的新生儿的维生素D3水平比自然受孕的新生儿高. 这一发现表明,从出生开始,这些群体之间的维生素D状况可能存在差异.
科学领域:
- 生殖医学 生殖医学
- 新生儿健康 新生儿健康
- 营养科学 营养科学
背景情况:
- 孕产妇维生素D不足与改善妊娠结果有关,包括临床妊娠和辅助生殖技术中的活产率.
- 母亲维生素D水平较低与妊娠前兆和晚期流产等不良结果有关.
- 由于缺乏维生素D的风险,丹麦的新生儿和幼儿建议补充维生素D.
研究的目的:
- 为了将体外受精 (IVF) 后出生的新生儿的维生素D3水平与普通人口的维生素D3水平进行比较.
- 根据受孕方法调查新生儿维生素D状态的潜在差异.
主要方法:
- 一项队列研究分析了丹麦1995年至2002年间出生的新生儿的维生素D3水平.
- 数据包括来自普通人口的1105名新生儿和通过试管婴儿受孕的1072名新生儿,这些新生儿通过国家注册表被确定.
- 测量25-基维生素D是从出生后48-72小时收集的干血斑点中进行测量.
主要成果:
- 通过试管婴儿受孕的新生儿的维生素D3水平中位数为33.0nmol/L (IQR 21.3-48.8).
- 来自普通人口的新生儿的维生素D3水平中位数为24.0nmol/L (IQR 14.1-39.3).
- 调整后的平均差异表明,试管婴儿新生儿的维生素D3水平显著更高 (6.1nmol/L).
结论:
- 在体外受精后出生的儿童与丹麦新生儿的随机样本相比,维生素D3水平更高.
- 这项研究强调了基于受孕方法的新生儿维生素D状况的差异.
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