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Updated: Jun 28, 2025

Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library
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Creating Highly Specific Chemically Induced Protein Dimerization Systems by Stepwise Phage Selection of a Combinatorial Single-Domain Antibody Library

Published on: January 14, 2020

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高通量DNA编码图书馆 关联性选择平台用于用固体支蛋白固定固定结合物识别

Ramón Rama-Garda1,2, Eduardo Domínguez3, María Isabel Loza2

  • 1Discovery Chemistry Research & Technologies, Lilly Research Laboratories, Eli Lilly and Company, Alcobendas, Spain.

Assay and drug development technologies
|April 19, 2024
PubMed
概括

一个新的自动化平台增强了DNA编码库 (DEL) 选用于连接体识别. 这种高通量系统提高了药物发现研究的亲和性选择 (AS) 的可重现性和灵活性.

关键词:
用DNA编码的图书馆.亲和关系的选择 亲和关系的选择自动化自动化自动化自动化质量控制质量控制质量控制

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Affinity Chromatography01:03

Affinity Chromatography

Affinity chromatography is a powerful technique extensively utilized for separating and purifying specific biomolecules from complex mixtures. It capitalizes on the highly selective binding between an analyte and its counterpart, such as antibody-antigen interactions. The counterpart is immobilized on the stationary phase, forming an affinity column. The stationary phase typically consists of solid support, such as agarose or porous glass beads, immobilizing the affinity ligand. The mobile...
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