三十年来,壮症并发症,治疗和结果的变化:全国范围的队列研究
Christian Rosendal1, Mai Christiansen Arlien-Søborg2, Eigil Husted Nielsen1
1Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
丹麦的壮症患者护理在三十年内得到了改善,生物化学控制更好,死亡率降低. 伴随性疾病增加,但癌症风险保持稳定,并且较少的患者出现下垂体激素缺乏症.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 巨症是一种罕见的内分泌疾病,由生长激素过量引起,与显著的发病率和死亡率有关.
- 长期的结果和不断变化的巨治疗策略需要持续调查.
研究的目的:
- 分析丹麦壮症患者特征,治疗,并发症和结局的时间趋势.
- 评估三十年来丹麦壮病患者癌症发病率和死亡率的变化.
主要方法:
- 追溯分析了1990年至2021年诊断的739名丹麦壮病患者.
- 数据按诊断/治疗开始十年 (1990年代,2000年代,2010年代) 分层.
- 评估腺瘤大小,IGF-I水平,并发症,治疗方式和死亡率.
主要成果:
- 随着时间的推移,糖尿病,心脏病,睡眠呼吸暂停,关节疾病和骨质疏松症的发病率增加.
- 死亡风险减半,癌症风险保持不变.
- 转向医学治疗,减少重复手术/辐射,改善IGF-I正常化率 (69%至88%).
- 在患有多重下垂体激素缺乏症的患者中显著减少.
结论:
- 改善的医疗治疗和增强的并发症管理导致丹麦更好地控制了壮病并降低了死亡率.
- 这项研究表明,与壮症护理演变相关的癌症风险没有增加.
- 现代的管理策略有助于改善壮病患者的生活质量和减少长期并发症.
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