在presbycusis中对低级和高级功能网络的拓干扰
Yixi Xu1, Xiangxiang Li2, Qi Yan3
1Department of Otolaryngology, Head and Neck Surgery, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Brain communications
|April 19, 2024
概括
与低级功能连接 (LOFC) 网络相比,高级功能连接 (HOFC) 网络在识别前症的认知障碍方面显示出更高的准确性. 对HOFC的分析揭示了大脑网络中的显著拓差异,大脑网络的前卫病患者.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 认知科学 认知科学
背景情况:
- 功能连接 (FC) 障碍与大脑的认知障碍有关.
- 之前的研究集中在一般的FC,但低级 (LOFC) 和高级 (HOFC) 功能连接的具体作用在presbycusis中仍然不太了解.
研究的目的:
- 为了研究前卫病患者在LOFC和HOFC网络中的拓结构重组.
- 为了比较LOFC和HOFC网络的分类性能,以确定presbycusis.
- 为了确定大脑网络的特殊差异,大脑病患者和健康的对照.
主要方法:
- 休息状态功能性磁共振成像 (Rs-fMRI) 数据从60名大病患者和50名健康对照 (HC) 获得.
- 构建了LOFC和HOFC网络,并分析了拓指标 (全球,节点,模块化,丰富俱乐部).
- 基于网络的统计 (NBS) 分析被用来识别改变的子网络.
主要成果:
- 无论是LOFC还是HOFC网络,在两个群体中都表现出小世界属性.
- 在LOFC和HOFC网络中,观察到长病患者和HC之间存在显著的拓差异.
- 与LOFC相比,HOFC档案显示出更高的分类准确性,敏感性和特异性,对大脑的特异性更高.
- 在HOFC网络中,NBS分析揭示了一个独特的子网络,其中有26个节点和23个改变的连接,在HOFC网络中的长病患者中.
结论:
- 与LOFC网络相比,HOFC网络揭示了与LOFC网络相比,前病患者的大脑网络的拓差异更为明显.
- HOFC网络分析提供了一种有前途的方法,可以增强与大脑关联的大脑网络异常的识别.
- 这些研究结果表明,HOFC可以改善老年痴呆症认知障碍的诊断和预后能力.
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