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格林增加了管的吸收在脏中的

Mingzhu Nie¹, Jing Zhang¹, Manjot Bal¹

¹Pediatric Nephrology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Frontiers in physiology

|April 19, 2024

概括

格林素缺乏可能会通过降低的脏再吸收,导致骨质疏松症. 这项研究表明,格林刺激的道,这表明格林,平衡和骨健康之间存在联系.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
骨的新陈代谢骨的新陈代谢

背景情况:

骨质疏松症是一个越来越多的担忧后腹部外科手术,与降低的,和 ghrelin 水平相关.
格林是一种胃激素,通过脏中存在的生长激素分泌受体 (GHSR) 调节新陈代谢.

研究的目的:

通过影响脏的 (TRPV5) 和 (TRPM6/7) 通道,调查林缺乏是否会导致骨质疏松症.
阐明格林在调节这些通道中的信号通路.

主要方法:

在体外研究中,使用表达GHSR的HEK293细胞与TRPV5或TRPM6 / 7进行TRPV5或TRPM6 / 7的实验,用ghrelin处理并通过补丁进行分析.
使用野生型和GHSR-null小鼠的体内研究,包括微解剖,qPCR,免疫光,以及在基线和热量限制下分析尿道分泌和血清水平.

主要成果:

格林剂量取决于TRPM6/7通道活性增加,但不是TRPV5,通过GHSR和Gαs-PKA信号传递.
在小鼠管 (TAL和DCT) 中发现了GHSRmRNA,TRPM6mRNA主要存在于DCT中,但也存在于TAL中.
与野生类型小鼠相比,GHSR-null小鼠的尿道分泌量增加,特别是当热量受限时,血清减少.

结论:

格雷林通过TRPM6/7通道通过GHSR/Gαs-PKA信号传递刺激的再吸收.
格林-GHSR信号似乎对于维持的平衡至关重要,特别是在卡路里限制期间,可能会影响骨健康.
饥饿期间林水平上升可能会增加的脏再吸收,以补偿饮食摄入量减少.

关键词:

在 GHSRR 找格林林 (Ghrelin) 是一种激素.TRPM6/76/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/77/TRPM6/TRPM6/TRPM6/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM77/TRPM7 is also known to have been known to have been known to have been 的含量是多少? 的含量是多少?蛋白质激酶A是一种蛋白质激酶.

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