压力过度反应性增加了患过度饮食和相关焦虑类行为的脆弱性;比较Wistar-Kyoto和Sprague-Dawley大鼠之间的比较
Daniela Sarai Rodríguez-Rangel1, Erika Estrada-Camarena2, Carolina López-Rubalcava1
1Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados (CINVESTAV-Sede Sur), Mexico City, Mexico.
Frontiers in nutrition
|April 19, 2024
概括
高压力敏感的老鼠 (WKY) 比标准老鼠 (SD) 更容易出现过度饮食和类似焦虑的行为. 这表明压力反应性是这些条件的关键脆弱性因素,即使没有额外的压力或卡路里限制.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 精神病学是一个精神病学.
背景情况:
- 暴饮暴食障碍 (BED) 很普遍,特别是在女性中,并且经常与焦虑症一起发生.
- 压力敏感性是BED和相关焦虑的潜在脆弱性因素.
- 维斯塔-京都 (WKY) 鼠株表现出压力过敏反应的表型,使其成为研究与压力相关行为的模型.
研究的目的:
- 为了调查WKY大鼠是否具有更高的应激反应能力,同时发展过度饮食类型和类似焦虑的行为.
- 为了比较WKY大鼠与Sprague Dawley (SD) 大鼠在发展这些行为方面的脆弱性.
主要方法:
- 在没有卡路里限制或外部压力因素的情况下,WKY和SD老鼠被暴露在间歇性获得美味食物 (糖糖或缩短) 的环境中.
- 评估过度饮食类型的饮食,类似焦虑的行为,以及血清皮质水平作为应激反应的衡量标准.
主要成果:
- 与SD大鼠相比,WKY大鼠的暴饮暴食行为发生率更高,发展速度更快.
- 与SD大鼠相比,WKY大鼠更容易发生类似焦虑的行为.
- 在WKY和SD大鼠中,糖过度饮食对下丘脑-垂体-上腺 (HPA) 轴的反应产生了不同的影响.
结论:
- 过度反应性压力表型是发展过度饮食类型和焦虑类型行为的一个常见的脆弱性因素.
- WKY大鼠很容易同时产生暴饮暴食和类似焦虑的行为,而这与食物成分无关.
- 这些发现凸显了压力敏感性在饮食和焦虑障碍的病因学中的作用.
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