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相关概念视频

The Vestibular System01:29

The Vestibular System

39.5K
The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
39.5K
Equilibrium and Balance01:15

Equilibrium and Balance

4.7K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.7K

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相关实验视频

Updated: Jun 28, 2025

An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy
11:52

An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy

Published on: June 13, 2013

11.9K

在小鼠前置器官中,TMC功能,功能障碍和恢复.

Evan M Ratzan1, John Lee1, Margot A Madison1

  • 1Department of Otolaryngology, F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States.

Frontiers in neurology
|April 19, 2024
PubMed
概括
此摘要是机器生成的。

TMC1和TMC2蛋白对听力和平衡至关重要. 失去TMC1会破坏前体唤起的潜能,但基因疗法可以恢复小鼠的功能.

关键词:
TMC1 TMC1 是一个TMC2 TMC2 的意思是什么?头发细胞是指毛细胞.一个小袋子,一个小袋子.一个半圆形的运河.这是一个极端的Utricle.这是前置体前置体.

更多相关视频

Surgical Labyrinthectomy of the Rat to Study the Vestibular System
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Surgical Labyrinthectomy of the Rat to Study the Vestibular System

Published on: May 19, 2018

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Behavioral Assessment of the Aging Mouse Vestibular System
09:30

Behavioral Assessment of the Aging Mouse Vestibular System

Published on: July 11, 2014

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相关实验视频

Last Updated: Jun 28, 2025

An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy
11:52

An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy

Published on: June 13, 2013

11.9K
Surgical Labyrinthectomy of the Rat to Study the Vestibular System
04:03

Surgical Labyrinthectomy of the Rat to Study the Vestibular System

Published on: May 19, 2018

10.1K
Behavioral Assessment of the Aging Mouse Vestibular System
09:30

Behavioral Assessment of the Aging Mouse Vestibular System

Published on: July 11, 2014

16.9K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科

背景情况:

  • TMC1和TMC2对于内耳的机械传感传导至关重要.
  • 它们在前体器官中的精确作用和表达模式需要进一步研究.

研究的目的:

  • 研究前置器官中TMC1和TMC2的表达和功能.
  • 为了确定TMC1和TMC2损失对前庭功能的影响.
  • 为了评估TMC1基因替代疗法的疗效.

主要方法:

  • 定量聚合酶连锁反应 (qPCR) 和光 in situ 杂交 - 链反应 (FISH-HCR).
  • 免疫覆盖,FM1-43吸收测定,以及前体唤起潜能 (VsEPs) 和前体眼反射 (VORs) 的测量.
  • 对Tmc1淘汰赛 (KO) 和Tmc2KO小鼠模型的分析.

主要成果:

  • TMC1和TMC2表现出动态的发育变化和独特的区域表达模式.
  • 在Tmc1 KO小鼠中,VsEPs和VORs都消失了,而在Tmc2 KO小鼠中,VsEPs依然存在.
  • 新生儿Tmc1基因替代疗法在Tmc1KO小鼠中恢复了VsEP,长达6个月.

结论:

  • TMC1和TMC2在前体机械传导中发挥着关键的,不同的作用.
  • TMC1对于前体唤起潜能和前体眼神反射是必不可少的.
  • TMC1基因替代疗法为前庭功能障碍提供了一个潜在的治疗策略.