对家禽进行高致病性禽流感疫苗接种 - - 第2部分. 监督和缓解措施的监督和缓解措施
EFSA journal. European Food Safety Authority
|April 19, 2024
概括
选择正确的诊断工具对于禽流感疫苗接种计划至关重要. 高灵敏度的分子方法最好用于检测疫苗接种家禽的病毒载荷降低,以及其他监测和疾病自由的测试.
科学领域:
- 兽医病毒学 兽医病毒学
- 免疫学 免疫学 免疫学
- 疾病监测 疾病监测
背景情况:
- 高致病性禽流感 (HPAI) 的有效疫苗接种计划需要仔细选择诊断方法.
- 疫苗接种成功的迹象是病毒载量减少,有利于敏感的分子诊断技术.
研究的目的:
- 评估在接种疫苗的家禽群体中对HPAI的诊断和监测策略.
- 推疫苗接种后安全搬运家禽的方案.
主要方法:
- 评估各种监测选项,包括对死鸟进行病毒学测试 ("桶样本") 和对活鸟进行病毒学或血清学测试.
- 对分子方法,病毒隔离,基因测序和表型特征的分析,用于早期检测HPAI和逃生突变.
- 对安全运输家禽的实验室检查的评估.
主要成果:
- 建议使用高灵敏度的分子方法在接种疫苗的群体中诊断HPAI,因为预计病毒载量较低.
- 对死鸟的病毒学测试和对子的活鸟的测试是有效的监测策略.
- 缩短采样间隔增加了早期检测的灵敏度,而搬运前的实验室检测可以减轻风险.
结论:
- 适当的诊断和监测策略对于在接种疫苗的家禽中管理HPAI至关重要.
- 建议采用综合方法,结合分子诊断,病毒表征和强有力的监测.
- 具体计划可以促进疫苗接种家禽的安全运输,确保疾病控制.
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