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多发性硬化症治疗对肠道微生物群失调的影响:一项纵向前性研究

Andreea-Cristina Paraschiv¹, Vitalie Vacaras^1,2, Cristina Nistor^1,2

¹Department of Neurosciences, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy Cluj- Napoca, 400012 Romania.

Microbial cell (Graz, Austria)

|April 19, 2024

概括

这项关于多发性硬化症 (MS) 肠道微生物群的研究发现了患者和对照群之间的特定细菌变化,而不是整体多样性差异. 疾病修饰疗法 (DMT) 和IgY补充剂等治疗方法可以帮助MS患者恢复更健康的肠道微生物群.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
神经学神经学

背景情况:

肠道微生物组在免疫系统功能中起着至关重要的作用,并与各种疾病有关,包括多发性硬化症 (MS).
了解患有多发性硬化症 (PwMS) 的人的肠道微生物组成以及它如何受到治疗的影响,对于开发治疗策略至关重要.

研究的目的:

研究疾病修饰疗法 (DMT) 和免疫球蛋白Y (IgY) 补充剂对MS患者肠道微生物群的影响.
为了比较PwMS和健康对照 (HC) 之间的肠道微生物多样性和组成.

主要方法:

该研究包括60名参与者:39名PwMS (20名DMT,19名DMT+IgY) 和21名HC.
在基线和两个月后收集肠道样本进行微生物分析,包括α和β多样性.
分类学分析确定了肠道微生物组内的特定细菌物种和家族.

主要成果:

在PwMS和HC组之间没有观察到α和β多样性的显著差异.
与HC相比,PwMS显示了Prevotella stercorea的增加和Faecalibacterium prausnitzii的减少,这表明dysbiosis.
在PwMS的两个月内,治疗导致了Lachnospiraceae和Streptococcus的丰富,以及Bifidobacterium angulatum和Oscillospira的变化.

结论:

与HC相比,肠道微生物群的多样性在PwMS中没有显著差异,但特定的分类学变化表明存在失生状态.
德米和IgY补充剂可能会诱导微生物组成的变化.
这些变化表明,通过治疗干预,可以在MS患者中恢复更健康的肠道微生物组.

关键词:

大脑肠子轴轴.脱髓化的自身免疫性疾病.我们的肠道微生物群.免疫球蛋白Y 免疫球蛋白Y 免疫调节免疫调节免疫调节微生物组是一个微生物组.多发性硬化症多发性硬化症

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