精神分裂症相关基因的亚洲-欧洲分化是由混合物和自然选择驱动的
Sihan Chen1, Die Tang1, Lian Deng1,2
1State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
对欧洲人的精神分裂症 (SCZ) 的全基因组关联研究可能不适用于亚洲人. 亚洲和欧洲人群在SCZ相关变异中表现出显著的遗传差异,突出显示需要多样化的样本纳入.
科学领域:
- 遗传学 遗传学 是一个
- 人口遗传学 人口遗传学
- 精神病学遗传学 精神病学遗传学
背景情况:
- 对精神分裂症 (SCZ) 的全基因组关联研究 (GWAS) 主要以欧洲为中心.
- 由于遗传多样性,这些研究可能对非欧洲人群的适用性有限.
研究的目的:
- 研究亚洲和欧洲人群之间的SCZ相关变异的遗传差异化.
- 为了确定潜在的本地适应和影响SCZ风险的古老内入,在不同的祖先.
主要方法:
- 使用公开的基因组数据分析了1592个报告的SCZ相关基因.
- 与SCZ相关的变异差异化与亚洲和欧洲祖先之间的全基因组水平的比较.
- 识别最近的本地适应和古老的侵入事件.
主要成果:
- 与全基因组水平相比,SCZ相关变异的亚洲-欧洲差异化明显更高.
- 特定的变种 (例如,SLC5A10-rs1624825,TSPAN18-rs1001292) 显示出显著的差异化.
- 最近的局部适应 (例如,亚洲人的LTN1-rs57646126-A,欧洲人的ZSWIM6-rs72761442-G) 和古老的内进 (阿尔泰-尼安德特人,1q21.2,3p21.31) 的证据,影响SCZ易感性在祖先之间不同.
结论:
- 精神分裂症的遗传结构在亚洲和欧洲人群之间有所不同.
- 最近的适应和古老的内进导致祖先特有的SCZ风险.
- 包括多样化的亚洲样本对于未来的精神分裂症GWAS至关重要,以提高概括性.
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