正常和病态肺微环境中的施万细胞
Michael R Shurin1,2, Sarah E Wheeler1, Galina V Shurin1
1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Frontiers in molecular biosciences
|April 19, 2024
概括
Schwann 细胞是关键的外周神经系统组成部分,显著影响肺癌的进展和转移. 了解它们在瘤-神经免疫轴中的作用,可能会揭示肺部瘤的新治疗点.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 呼吸系统依赖于复杂的神经调节来控制肺部发育,功能和疾病反应.
- 肺部疾病导致全球显著的死亡率,肺癌是癌症死亡的主要原因.
- 虽然呼吸道神经已得到认可,但神经质细胞在肺病理生理学,特别是肺癌中的作用仍然未被充分探索.
研究的目的:
- 研究施万细胞在肺癌发育和进展中的作用.
- 阐明施万细胞影响肺癌细胞的细胞和分子机制.
- 探索向瘤-神经免疫轴的潜力,涉及用于肺癌治疗的施万细胞.
主要方法:
- 在体外和体内研究中,研究了施万细胞与肺癌细胞的相互作用.
- 分析施万细胞分泌的因素,如微RNA.
- 肺癌相关的 Schwann 细胞数量与患者存活率之间的相关性研究.
主要成果:
- 施万细胞调节肺癌细胞的生存,扩散和侵入性.
- 施万细胞有助于肺癌微环境,并支持转移.
- 与肺癌相关的 Schwann 细胞的数量与患者的存活率相关.
- 施万细胞分泌的因素,包括微RNA,调节瘤-神经免疫轴.
结论:
- 施万细胞在塑造肺癌微环境和促进转移方面发挥着至关重要的作用.
- 施万细胞是肺瘤-神经免疫轴的组成部分.
- 对施万细胞在肺癌发病过程中的作用进行进一步的研究对于开发新的治疗策略至关重要.
更多相关视频
07:39The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues
Published on: June 16, 2018
9.3K
06:27Author Spotlight: Modeling Human Airway Remodeling and Viral Responses Using Isogenic Epithelial, Endothelial, and Immune Cells
Published on: December 6, 2024
977
相关概念视频
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:26Stem Cell Niche
5.1K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.1K