使用Juemingzi (花种子提取物) 对人类肠道微生物组进行有针对性的重塑
Adrienne B Narrowe1, Johanna M S Lemons1, Karley K Mahalak1
1Dairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Wyndmoor, PA, United States.
Frontiers in cellular and infection microbiology
|April 19, 2024
概括
朱明芝 (种) 提取物显著减少了肠道细菌,几乎消除了Bacteroidota,同时促进了Enterobacteriaceae和Actinomycetota,改变了发酵产品.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
背景情况:
- 塞纳属具有传统的医疗用途,其中诸如塞诺西德和埃莫丁等化合物显示出抗菌潜力.
- 关于Senna化合物组合对完整的人体肠道微生物群的影响的研究有限.
研究的目的:
- 评估Juemingzi (参种) 提取物对人类肠道微生物组的组成和功能的影响.
- 在受控的肠道环境中研究Senna种子提取物对抗微生物和发酵的影响.
主要方法:
- 利用系统性肠道发酵研究 (SIFR®) 技术进行48小时的人体便化.
- 通过中枪元基因组测序评估了总细菌细胞密度,发酵产品 (pH,气体,SCFA) 和微生物群体结构.
主要成果:
- 朱明芝提取物表现出特定类别的抗菌作用,将总细胞密度降低了40%并减少了微生物多样性.
- 细菌杆菌的数量显著减少,而肠杆菌群和某些细菌杆菌的数量持续存在,导致气体和酸盐的产量增加,pH值降低.
结论:
- 塞纳种子提取物显示出强大的,针对肠道微生物的特异性抗菌活性,特别是Bacteroidota.
- 提取物诱导微生物群落结构和发酵概况的显著变化,表明有针对性的微生物组调节的潜力.
关键词:
细菌杆菌的发生.它们是Enterobacteriaceae的细菌.这就是SIFR®.塞纳 塞纳 塞纳 塞纳它们是ex vivo,ex vivo.我们的肠道微生物组.转基因组学是指转基因组学.临床前研究 临床前研究更多相关视频
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