大麻种子减轻了小鼠的洛佩拉胺诱导的便秘
Huang Hua1, Wang Yongtong1, Ding Xufeng1
1Department of Anorectal Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, China.
大麻种子 (HS) 和其提取物 (HSE) 通过改善肠道运动性和减少结肠炎症,缓解小鼠的便秘. 这些影响与肠道微生物群的改变和有益的短链脂肪酸的增加有关.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 便秘是一种普遍的胃肠道疾病,影响整体健康.
- 建议使用大麻种子来缓解便秘,但机制尚不清楚.
研究的目的:
- 调查大麻种子 (HS) 和其水乙醇提取物 (HSE) 在减轻小鼠中洛佩拉胺诱导的便秘的疗效.
- 阐明潜在的机制,包括对胃肠道运动,炎症,短链脂肪酸和肠道微生物群的影响.
主要方法:
- 洛佩拉胺诱导的小鼠便秘模型.
- 评估便中的水含量和小肠经过率.
- 测量血清中的胃肠道激素 (胃素,莫提林,P物质,内分泌物).
- 结肠组织的组织病理学分析 (H&E染色).
- 对短链脂肪酸 (SCFA) 和肠道微生物组合物的分析.
主要成果:
- HS和HSE显著增加了便中的水含量和小肠过渡率,缩短了第一次排便的时间.
- 在HS和HSE调节的血清中,Gastrin,Motilin,P物质和Endothelin的水平.
- 观察到结肠炎症的改善,SCFA水平的增加,以及肠道微生物群 (Odoribacter, Bacteroides, Lactobacillus, Prevotella) 丰度的改变.
- HS和HSE在刺激有益的肠道微生物和促进肠道运动方面表现出潜力.
结论:
- 大麻种子及其提取物通过增强肠道运动和减少炎症,显示出缓解便秘的潜力.
- 治疗效果可能通过调节胃肠道激素,SCFA和肠道微生物群组成来调节.
- HS和HSE代表了改善肠道健康和控制便秘的有希望的自然干预措施.
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