在没有痴呆症的老年人中,神经心理症状和白质过强度
Ioannis Liampas1, Vasileios Siokas1, Elli Zoupa2
1Department of Neurology, University Hospital of Larissa, School of Medicine, University of Thessaly, Larissa, Greece.
International psychogeriatrics
|April 19, 2024
概括
广泛的白质超强度 (WMH) 与认知不受损的老年人中神经精神症状 (NPS) 的增加有关. 这种关联在轻度认知障碍 (MCI) 患者中没有观察到.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 神经成像是一种神经成像.
背景情况:
- 神经精神症状 (NPS) 在老年人中很常见,可能会影响生活质量.
- 白质过强度 (WMH),通常通过MRI检测,与衰老和脑血管疾病有关.
- 没有痴呆症的个体中WMH和NPS之间的关系,特别是认知不受损 (CU) 和轻度认知障碍 (MCI) 组之间的区别,需要进一步调查.
研究的目的:
- 为了研究白质强度 (WMH) 的严重程度与老年人神经精神症状 (NPS) 的存在之间的关联.
- 为了确定这种关联是否在认知正常 (CU) 个体和轻度认知障碍 (MCI) 个体之间有所不同.
主要方法:
- 分析了来自国家阿尔茨海默氏症协调中心统一数据集的纵向数据.
- 参与者 (≥50岁) 被归类为认知不受损 (CU) 或轻度认知障碍 (MCI).
- 白质超强度 (WMH) 通过心血管健康研究 (CHS) 评分来量化,神经精神症状 (NPS) 通过神经精神病 inventory 问卷进行评估.
- 采用二进制物流回归模型来评估基于CU和MCI组的WMH状态的NPS概率.
主要成果:
- 在认知不受损 (CU) 的老年人中,广泛的WMH与经历高兴,无抑制,激动和焦虑的更高几率显著相关,与没有轻微WMH的人相比.
- 适度的WMH与CU组的抑制率增加有关.
- 在轻度认知障碍 (MCI) 组中,在WMH严重程度和经历神经精神症状的几率之间没有发现显著的关联.
结论:
- 广泛的白质超强度 (WMH) 与在认知不受损的老年人中增加神经精神症状 (NPS) 的可能性有关.
- 在轻度认知障碍 (MCI) 患者中,WMH和NPS之间的这种关联并不明显.
- 研究结果表明,WMH可能会在认知衰退的临床前阶段导致NPS,但在MCI阶段,其他因素可能更有影响力.
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