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通过动态组合化学,发现了选择性单糖受体

Miguel Alena-Rodriguez1,2, Marcos Fernandez-Villamarin1, Ignacio Alfonso2

  • 1School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, UK. p.m.mendes@bham.ac.uk.

Organic & biomolecular chemistry
|April 19, 2024
PubMed
概括

研究人员开发了一种新方法来发现与糖结合的合成受体. 他们发现了一种简单的分子,1F,对果糖具有很高的亲和力和选择性,加速了碳水化合物受体的发展.

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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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