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Updated: Jun 28, 2025

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YAP和TAZ差异性调节产后皮层原始细胞的增殖和天体细胞的分化

Jessie Chen1, Yung-Hsu Tsai1, Anne K Linden1

  • 1Department of Neurology, Northwestern University's Feinberg School of Medicine, Chicago, IL 60611, USA.

Journal of cell science
|April 19, 2024
PubMed
概括

含WW域的转录调节器1 (TAZ) 和Yes相关蛋白 (YAP) 在神经干细胞发育中具有不同的作用. TAZ促进星体细胞成熟,而YAP影响原生细胞周期,揭示了星体细胞分化中的不同的功能.

关键词:
星球细胞是星球细胞.在BMP中,BMP是BMP.整合物是一种整合物.神经干细胞的神经干细胞塔兹塔兹是什么意思?塔兹塔兹是什么意思哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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