同热量,时间限制饮食对肥胖成年人体重的影响:一项随机对照试验
Nisa M Maruthur1, Scott J Pilla2, Karen White3
1Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore; Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore; and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland (N.M.M., L.J.A., E.G., J.M.C.).
Annals of internal medicine
|April 19, 2024
概括
时间限制饮食 (TRE) 不会导致独立于卡路里摄入量的体重减轻. 这项研究发现,与卡路里稳定时的通常饮食模式相比,TRE没有显著的体重或葡萄糖改善.
科学领域:
- 代谢和内分泌学
- 肥胖问题研究研究
- 糖尿病管理 糖尿病管理
背景情况:
- 时间限制饮食 (TRE) 经常被研究为减肥,但其独立于减少卡路里的效果仍然不清楚.
- 动物研究表明,TRE可能会诱导体重减轻,无论热量摄入量如何,这一发现尚未在人体试验中得到证实.
研究的目的:
- 在同热量条件下,研究TRE对体重的影响与通常的饮食模式 (UEP) 相比.
- 评估TRE是否会影响体重减轻,而不影响卡路里消耗的变化.
主要方法:
- 一项为期12周的随机同热量养研究,涉及肥胖和糖尿病前期/饮食控制糖尿病的成年人.
- 参与者被分配到TRE (10小时的进食窗口) 或UEP (≤16小时的窗口) 中,其营养含量和总热量摄入量与基线测量相同.
主要成果:
- 在12周后,TRE组 (-2.3公斤) 和UEP组 (-2.6公斤) 之间没有观察到体重变化的显著差异 (平均差异:0.3公斤).
- 二次结果测量,包括禁食葡萄糖和胰岛素耐药性 (HOMA-IR),也显示两种饮食模式之间没有显著差异.
结论:
- 在稳定,同热量饮食的背景下,与UEP相比,TRE没有导致更大的体重减轻或改善葡萄糖平衡.
- 这些发现表明,在以前的TRE研究中观察到的体重减轻可能主要归因于相关的总体热量摄入量的减少,而不是饮食时间本身.
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