通过加载到各种药物输送系统来减轻多克索鲁比的副作用:一项比较性研究
Rehab M Abdel-Megeed1, Hassan Z Ghanem1, Mai O Kadry1
1Therapeutic Chemistry Department, Pharmaceutical & Drug Industries Research Institute, National Research Center, El Buhouth St, Dokki, Cairo, 12622, Egypt.
Therapeutic delivery
|April 19, 2024
概括
新的多克索鲁比辛配方在克服肝细胞癌 (HCC) 耐药性方面表现有前途. 在HCC模型中,载多克索鲁比 (TiO2-Dox),多克索鲁比-乳酸和PEGylated多克索鲁比有效调节生物标志物和基因表达.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 药物运输 药物运输 药物运输
背景情况:
- 肝细胞癌 (HCC) 仍然是一个重要的治疗挑战,主要是由于获得的耐药性.
- 多克索鲁比耐药性和复杂的受体间交叉通路阻碍了HCC的有效治疗策略.
- 新型药物输送系统对于提高治疗疗效和克服HCC的耐药性机制至关重要.
研究的目的:
- 研究各种多克索鲁比辛配方在肝细胞癌中克服多克索鲁比辛耐药性的疗效.
- 评估新型多克索鲁比辛配方对与HCC进展和耐药性相关的关键生物化学和分子标记物的影响.
- 为肝细胞癌确定有前途的治疗方案,可以绕过现有的抵抗机制.
主要方法:
- 肝细胞癌在动物模型中被诱导使用3-甲基chloroanthrene.
- 随后,动物接受了多克索鲁比辛,脂质体多克索鲁比辛,含多克索鲁比辛 (TiO2-Dox),乳酸铁素多克索鲁比辛和PEG化多克索鲁比辛的治疗.
- 进行了全面的生化和分子分析,以评估治疗效果.
主要成果:
- 3-甲基chloroanthrene的使用显著改变了和的度.
- 观察到瘤生物标志物的水平升高,包括阿基纳-I和α-L-Fucodinase.
- 检测到C-myc,Hprt-1和EGFR基因的过度表达,表明瘤进展.
- 所有测试的多克索鲁比辛配方都显示了测量生物化学和分子参数的显著调节.
结论:
- 含的多克索鲁比辛 (TiO2-Dox),多克索鲁比辛-乳酸和PEGylated doxorubicin显示出作为肝细胞癌的治疗策略的显著潜力.
- 这些新型配方可能提供一种可行的方法来克服HCC中多克索鲁比辛耐药性.
- 对这些有前途的治疗方案的进一步研究可能会为HCC患者改善治疗结果.
更多相关视频
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
10.9K
09:09Synthesis of Aptamer-PEI-g-PEG Modified Gold Nanoparticles Loaded with Doxorubicin for Targeted Drug Delivery
Published on: June 23, 2020
6.0K
相关概念视频
01:21Drug Distribution: Tissue Binding
2.6K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
For...
2.6K
01:16Drug Delivery: Overview
289
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
289
01:22Drug Delivery: Miscellaneous Routes
338
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
338
01:26Enhanced Elimination of Poison
505
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
505
01:18Drug Delivery: Enteral Route
428
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
428
01:25Routes of Drug Administration: Parenteral
1.9K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
1.9K