血中的,遗传风险和发生石的风险:基于人口的队列研究
Xi Cao1, Si Li1, Yunlong Guan1
1Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Mayo Clinic proceedings
|April 19, 2024
概括
高血水平和遗传倾向显著增加结石的风险. 患有这两种因素的人面临复合风险,这突显了针对性预防策略的必要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 结石是一种常见的疾病,具有多因素的原因.
- 了解遗传易感性与血等生化因素之间的相互作用对于风险分层至关重要.
研究的目的:
- 为了检查血液度和结石发病率之间的关联.
- 评估遗传倾向在结石发育中的作用,通过多基因风险评分 (PRS) 评估.
- 为了研究血水平与结石遗传风险之间的潜在相互作用.
主要方法:
- 一项基于人口的队列研究,利用英国生物库的数据.
- 多变量Cox比例危险回归模型用于计算危险比率 (HR) 和95%置信区间 (CI).
- 分析包括与血水平和PRS相关的石事件风险,并探索它们的相互作用.
主要成果:
- 较高的血液度 (第三位) 与较低的第三位相比,患结石的风险增加了24% (HR: 1.24,95% CI: 1.15-1.33).
- 增加的遗传风险,特别是PRS的最高五分位数,显示结石的风险增加了70% (HR: 1.70,95%CI: 1.53-1.89).
- 观察到一个共同的累积风险,表明血升高和高遗传易感性协同增加结石发病率.
结论:
- 血度和多基因风险评分 (PRS) 都是发生结石风险的重要独立预测因素.
- 具有高遗传风险的个体可能会经历结石的扩大风险与过高的血水平.
- 血水平和患结石的风险之间存在非线性关系.
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