通过透气导管用跨管内系统替换米特拉的两年临床和心声监测跟踪
Vinayak Bapat1, Eric Weiss2, Tanvir Bajwa2
1St. Thomas' Hospital, London, United Kingdom; New York Presbyterian/Columbia University Medical Center, New York, New York, USA.
JACC. Cardiovascular interventions
|April 19, 2024
概括
在两年内,Intrepid跨 (TA) 跨导管 mitra 置换 (TMVR) 系统在患有严重 mitra 吐 (MR) 的高风险患者中显示出改善的结果. 尽管有早期死亡率和出血,但大多数患者经历了更好的功能类和减少了MR的严重程度.
科学领域:
- 心血管医学 心血管医学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 在此之前的30天内,Intrepid跨管 (TA) 跨导管中枢置换系统 (TMVR) 的结果显示技术上取得了成功.
- 在更大的患者队列中需要长期的结果进行评估.
研究的目的:
- 评估Intrepid TA-TMVR系统的两年安全性和性能.
- 为了评估症状,中度至重度额头回 (MR) 和高手术风险的患者的结局.
主要方法:
- 252名患有中度至重度MR的高风险患者被纳入试点研究和APOLLO试验.
- 临床事件和心声回声被独立判断和评估.
- 患者的随访时间长达2年.
主要成果:
- 2年后,全因死亡率为36.2%,心力衰竭再住院率为36.2%.
- 82.1%的幸存者改善到NYHA功能类I/II.
- 所有可用心声图的患者都有轻度或较小的MR.
结论:
- 这项研究代表了经过最长的随访时间报告的最大的跨吸管TMVR经验.
- 早期死亡率和再住院率显著,与TA相关的出血有关.
- 在两年内,Intrepid TA-TMVR系统显示出显著的临床改善,并减少了MR的严重程度.
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